WebHigh-resolution imaging reveals that the phosphorylation-state of FMRP can modulate the clustering of F MRP granules and thereby regulate local protein synthesis at the level of individual granules. Fragile X messenger ribonucleoprotein (FMRP) is an RNA-binding protein that can form granules within neurons. Although FMRP-containing Fragile X … WebFeb 14, 2024 · We first performed in vitro phosphorylation of recombinant FMRP LCR (phospho-FMRP LCR) by using CKII, a kinase that phosphorylates FMRP in vivo and …
Phosphorylation influences the translation state of FMRP …
WebEffect of acute stress on FMRP phosphorylation by Akt-mTOR and MAPK pathways in rat hippocampus. Felipe Aguayo Otros creadores. Fondecyt 1120528 "Proteins associated to synaptic remodeling are regulated differentially by stress and anti depressants: relationship with microRNAs levels". Dra Jenny Fiedler WebDec 26, 2007 · FMRP Phosphorylation Reveals an Immediate-Early Signaling Pathway Triggered by Group I mGluR and Mediated by PP2A Journal of Neuroscience Previous Next Articles, Neurobiology of Disease FMRP Phosphorylation Reveals an Immediate-Early Signaling Pathway Triggered by Group I mGluR and Mediated by PP2A cup chickpeas calories
Roles of fragile X mental retardation protein in dopaminergic ...
WebFMRP has also been shown to undergo the post-translational modifications of arginine methylation and phosphorylation, as well as alternative splicing, resulting in multiple isoforms. The alternative splice isoforms investigated in this study, isoform 1 (ISO1), isoform 2 (ISO2), and isoform 3 (ISO3), are created by the alternative splicing ... WebThe phosphorylation of FMRP (S500 human, S499 mouse) occurs in the C-terminal region, suggesting that phosphorylation initiates a conformational change in the molecule, allowing it to interact more strongly with AGO in the N-terminus. Likewise, the binding of the N-terminus of MOV10 to FMRP’s KH1 domain most likely changes the conformation of ... WebMar 15, 2024 · Our high resolution approach can reveal how the phosphorylation-state of FMRP can modulate the clustering of FMRP granules and thereby regulate local protein synthesis at the level of individual granules. Competing Interest Statement The authors have declared no competing interest. Copyright cup chicken noodles