Trifluoromethylthiolating

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August undefined, 2024

WebA new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes.N-trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, … WebApr 20, 2024 · In this review, recent advances in trifluoromethylthiolation using nucleophilic trifluoromethylthiolating reagents are discussed, highlighting some of the most intriguing examples of the synthesis ...

Oxidative decarboxylative radical trifluoromethylthiolation of alkyl ...

WebApr 28, 2014 · ConspectusThe trifluoromethyl group is widely prevalent in many pharmaceuticals and agrochemicals because its incorporation into drug candidates could … WebApr 2, 2024 · Chinese Chemical Letters 2024年1期. Chinese Chemical Letters的其它文章 Diverse synthesis of the C ring fragment of bryostatins via Zn/Cu-promoted conjugate addition of α-hydroxy iodide with enone iowa city kickers soccer

Exploration of the Synthetic Potential of Electrophilic ...

WebMar 3, 2015 · A simplified electrophilic trifluoromethylthiolating reagent 1c was then identified that can react with a wide range of nucleophiles such as Grignard reagents, arylboronic acids, alkynes, indoles, β-ketoesters, oxindoles, and sodium sulfinates under mild reaction conditions. A variety of functional groups were tolerated under these conditions. WebMay 22, 2024 · Trifluoromethylthiolating reagent 3 was synthesized according to a procedure by Shen and co-workers. (23) Trifluoromethylating reagent 6a … WebA boron-catalyzed direct α-trifluoromethylthiolation of carboxylic acids was developed. Catalytically generated boron enediolates reacts with electrophilic SCF3 reagent, N-SCF3-phthalimide, to provide α-SCF3 carboxylic acids without the need of substrate pre-activation. The method is applicable to direct modification of bioactive carboxylic ... iowa city kickers summer camp

N‐Trifluoromethylthiosaccharin: An Easily Accessible, Shelf‐Stable ...

Structure-reactivity relationship of trifluoromethanesulfenates ...

WebApr 4, 2024 · Gilicinski and co-workers in 1992 made the first effort toward to quantitatively ordering the reactivity of electrophilic N-F fluorinating reagents. 49 They reported electrochemical measurements on the reduction reaction of a series of electrophilic N-F fluorinating agents. A qualitative correlation was found between the potential for the first … WebA H 2 O mediated practical and highly regioselective chloro- and bromo-trifluoromethylthiolation of sulfur ylides is reported using a difunctionalization strategy. In … iowa city knittingWebJul 7, 2014 · A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from … iowa city landing

"WebA new parameter, trifluoromethylthio cation-donating ability (Tt+DA), is introduced as a quantitative descriptor for the propensity of electrophilic trifluoromethylthiolating … " - Trifluoromethylthiolating

Trifluoromethylthiolating

Exploration of the Synthetic Potential of Electrophilic ...

WebMar 30, 2016 · Enantioselective trifluoromethylthiolation, especially of alkenes, is a challenging task. In this work, we have developed an efficient approach for … WebMar 30, 2016 · With regard to the high lipophilicity of the trifluoromethylthio group (CF 3 S–), there is a growing interest in the development of efficient methods for the incorporation …

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WebA new high yielding method for the preparation of a shelf-stable electrophilic trifluoromethylthiolating reagent, N-(trifluoromethylthio)phthalimide, is described. Reaction of this reagent with a variety of aryl and vinyl boronic acids in the presence of a copper catalyst generated the trifluoromethylthiolated arenes and alkenes in good to excellent … WebAug 18, 2024 · The recent recognition of the novel application of a few traditional electrophilic trifluoromethylthiolating reagents as SCF 3 radical sources offers a remarkable new opportunity for the development of radical trifluoromethylthiolation reactions. Herein, the first trifluoromethylthio radical donating ability (Tt • DA) scale of electrophilic SCF 3 …

WebThe invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions. WebMay 19, 2015 · To address these problems, in late 2011 we initiated a project with the aim to develop new, shelf-stable, and highly reactive electrophilic trifluoromethylthiolating …

WebSubstitution by the CF 3 S group allows for an increase in lipophilicity and electron-withdrawing properties along with an improvement in the bioavailability of medicinal … WebMay 18, 2024 · In this review, special attention is given to the preparation of (hetero)aryl C–H bonds by Friedel–Crafts-type trifluoromethylthiolation and transition-metal-catalyzed …

WebA transition-metal-free direct trifluoromethylthiolation of indole derivatives under mild conditions has been developed. Commercially available sodium trifluoromethanesulfinate …

WebJun 5, 2024 · a, Asymmetric trifluoromethylthiolation with electrophilic trifluoromethylthiolating reagents. b , Asymmetric trifluoromethylthiolation through … ooly watercolor paint podsWebIn this context, Liang's research group developed an operationally simple method for the direct trifluoromethylthiolation–difluoroalkylation of alkenes employing (bpy)CuSCF 3 (bpy = 2,2′-bipyridine) and ethyl iododifluoroacetate (ICF 2 CO 2 Et) as trifluoromethylthiolating and difluoroalkylating reagents, respectively. 13 Various styrene derivatives 4 slowly reacted … ooly watercolorWebEnantioselective trifluoromethylthiolation, esp. of alkenes, is a challenging task. The authors have developed an efficient approach for enantioselective trifluoromethylthiolating lactonization by designing an indane-based bifunctional chiral sulfide catalyst and a shelf-stable electrophilic SCF3 reagent. oom-9 voice actorWebAug 15, 2024 · Electrophilicity parameters (E) of some popular trifluoromethylthiolating and difluoromethylthiolating reagents were determined by following the kinetics of their reactions with a series of ... ooly yummy scented pensWeb赵霞，女，理学博士，教授，博士生导师。2002年9月至2006年7月在南开大学攻读学士学位。 2006年9月至2011年7月在北京大学攻读博士学位。2008年9月至2011年7月,在日本北海道大学亚洲联合研究生院攻读博士学位。2011年7月进入天津师范大学化学学院工作至今。其间，2012年入选天津市131人才第三层次人选 ... iowa city johnson county taxWebMay 20, 2014 · Furthermore, we also achieved the oxidative trifluoromethylthiolation reactions of aryl boronic acids and terminal alkynes to construct carbon-SCF3 bonds by using CF3SiMe3 and elemental sulfur as the nucleophilic trifluoromethylthiolating reagent. ooma 2602w headsetWebAug 26, 2024 · Here we describe a deoxygenative trifluoromethylthiolation method that yields trifluoromethyl thioesters from readily available carboxylic acids. The method is built upon an “umpolung” strategy where triphenylphosphine is used to first activate an electrophilic trifluoromethylthiolating reagent and then serves as an oxygen acceptor for … iowa city juneteenth